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GSK 3BETA
Descriptors Found:
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DeCS
Descriptor
English
:
Glycogen Synthase Kinase 3 beta
Descriptor
Spanish
:
glucógeno sintasa cinasa 3 beta
Descriptor
Portuguese
:
Glicogênio Sintase Quinase 3 beta
Synonyms
English
:
GSK 3beta
GSK-3beta
GSK3B Protein
GSK3beta
Tree Number:
D05.500.117.875.500
D08.811.913.696.620.682.700.429.500.500
D08.811.913.696.620.682.700.646.625.500
D12.644.360.300.500.500
D12.776.476.081.875.500
D12.776.476.300.500.500
Definition
English
:
A
glycogen synthase
kinase-3 type enzyme that functions in
ENERGY METABOLISM
;
EMBRYONIC DEVELOPMENT
; and
NEUROGENESIS
. It is also involved in
PROTEIN BIOSYNTHESIS
and regulates cell
growth
and proliferation as a component of the
WNT SIGNALING PATHWAY
and other signaling pathways. Certain polymorphisms in the GSK3B gene have been associated with
PARKINSON DISEASE
;
ALZHEIMER DISEASE
; and
BIPOLAR DISORDER.
History Note
English
:
2017 (2002)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
56432
Unique Identifier:
D000071679
Occurrence in VHL
:
Similar:
DeCS